Sunday, July 27, 2014

Magic health benefits of olive oil

  • HEART DISEASE

    Olive oil lowers the levels of total blood cholesterol, LDL-cholesterol and triglycerides. At the same time it does not alter the levels of HDL-cholesterol (and may even raise them), which plays a protective role and prevents the formation of fatty patches, thus stimulating the elimination of the low-density lipoproteins.
    • CANCER

      The phytonutrient in olive oil, oleocanthal, mimics the effect of ibuprofen in reducing inflammation, which can decrease the risk of breast cancer and its recurrence. Squalene and lignans are among the other olive oil components being studied for their possible effects on cancer.
      • BLOOD PRESSURE

        Recent studies indicate that regular consumption of olive oil can help decrease both systolic and diastolic blood pressure.
        • OBESITY

          Although high in calories, olive oil has shown to help reduce levels of obesity.

        • OSTEOPOROSIS

          A high consumption of olive oil appears to improve bone mineralization and calcification. It helps calcium absorption and so plays an important role in aiding sufferers and in preventing the onset of Osteoporosis.

Saturday, July 26, 2014

Papaverine injection for erectile dysfunction

 Papaverine is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral

spasm, vasospasm and treatment of erectile dysfunction.

Papaverine hydrochloride was initially the most often used medication. Papaverine

injections relax the muscle cells present in the arterial wall, causing dilation and increased

blood flow in the penis. Several researchers have also noted that a second Papaverine 

injection reduces the blood flow out of the penis, so that the blood is trapped and the erection

is maintained. The success rate, defined by the production of an erection rigid enough for

intercourse, has been in excess of 75%.


While all PDE5 inhibitors(Sildenafil) have become the most prescribed medication for the 


treatment of ED, injection therapy still represents a cornerstone of therapy.

How to use:

Cleanse the injection site with alcohol. Using a sterile needle, inject the medicine slowly and

directly into the base of the penis as instructed by your doctor. Papaverine should not be

injected just under the skin. The injection is usually not painful, although you may feel some 

tingling in the tip of your penis. If the injection is very painful or you notice bruising or swelling

at the place of injection, that means you have been injecting the medicine under the skin.

Stop, withdraw the needle, and reposition it properly before continuing with the injection.


After you have completed the injection, put pressure on the place of injection to prevent

 bruising. Then massage your penis as instructed by your doctor. This helps the medicine

spread to all parts of the penis, so that it will work better.

Dose:
Adults—30 to 60 milligrams (mg) injected very slowly into the area of your penis as directed

by your doctor. Allow one or two minutes to completely inject the dose. Do not inject more

than one dose in a day. Also, do not use this medicine  more than three times a week.

Friday, July 18, 2014

Topamax for adult migraine prevention

A migraine headache can cause intense throbbing or a pulsing sensation in one area

of the head and is commonly accompanied by nausea, vomiting, and extreme

sensitivity to light and sound,
which typically affects one half of the head.

It consists of prodromal(2days before) symptoms as constipation and depression, then

Aura (last 20-60 minutes)which present as visual disturpance and pin and needles

sensation in an arm or leg, then attack 
 the headache is unilateral, throbbing, and

moderate to severe in intensity(may be bilateral)
 It usually comes on gradually and is

aggravated by physical activity.Thé pain is frequently accompanied by nausea, 


vomiting, sensitivity to light, sensitivity to sound, sensitivity to smells, fatigue and 


irritability.
the U.S. Food and Drug Administration approved Topamax (topiramate) for prevention

(prophylaxis) of migraine 
headaches in adolescents ages 12 to 17. It widens the blood vessels

in the brain which become restricted by increased serotonin levels. It has been found

to be increasingly effective for migraine sufferers with limited side effects.
Topamax relativlly the best medication for prevention of migraine , there are also other

medications for

prevention as sodium valproate, propranolol, and metoprolol,Amitriptyline and venlafaxine

The common side effects :


  • Dizziness nausea ,depression , fatigue , somnolence

Wednesday, July 16, 2014

Natesto (testosterone) Nasal Gel for hypogonadism

 the United States Food and Drug Administration (FDA) has approved Natesto (testosterone),  the first

and only testosterone nasal gel for replacement therapy in adult males for conditions

associated with a 
and only testosterone nasal gel for replacement therapy in adult males for

conditions associated with a 
and only testosterone nasal gel for replacement therapy in adult

 males for conditions associated with a 
and only testosterone nasal gel for replacement

therapy in adult males for conditions associated with a 
and only testosterone nasal gel for

replacement therapy in adult males for conditions associated with a 
and only testosterone

nasal gel for replacement therapy in adult males for conditions associated with a 
and only

testosterone nasal gel for replacement therapy in adult males for conditions associated with

deficiency or absence of endogenous testosterone. Natesto is self-administered via a

nasal applicator thereby .

 
uses and indications :
 
Primary hypogonadism (congenital or

acquired):
testicular failure due to conditions

such as
cryptorchidism, bilateral torsion,

orchitis, vanishing
testis syndrome,

orchiectomy, Klinefelter's

syndrome,chemotherapy, or toxic damage from

alcohol or heavy metals. These men usually have low serum testosterone concentrations

and gonadotropins (follicle-
stimulating hormone [FSH], luteinizing hormone [LH]) above the

normal range.
Hypogonadotropic hypogonadism (congenital or acquired): idiopathic

gonadotropin or luteinizing
hormone-releasing hormone (LHRH) deficiency or pituitary-

hypothalamic injury from tumors, trauma, or
radiation. These men have low testosterone

serum concentrations but have gonadotropins in the normal or low range.

.
2 pump 
actuation per nostril administered intranasally three times daily for a total daily
dose of 33 mg.

The recognized side effects:

 prostate specific antigen (PSA) increased, headache, rhinorrhea, epistaxis, nasal discomfort,

nasopharyngitis, upper respiratory tract infection (URI), sinusitis, bronchitis



Tuesday, July 15, 2014

Metronidazole 1.3% Vaginal Gel for vginosis

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.

 Metronidazole is an antibacterial against anaerobic organisms, amoebicide and antiprotozoal. It is the drug

of choice for first episodes of mild-to-moderate Clostridium difficile infection.

 Giardia lamblia and ameba are intestinal parasites that can cause abdominal pain and diarrhea in infected 


individuals. Trichomonas is a vaginal parasite that causes inflammation of the vagina (vaginitis). Metronidazole

selectively blocks some of the functions within the bacterial cells and the parasites resulting in their death.

The FDA approval of Metronidazole vaginal gel 1.3% was based on a phase III randomized, double-blind, placebo-


controlled, multicenter clinical trial. Metronidazole 1.3% was compared to MetroGel-Vagina (metronidazole


 vaginal gel 0.75%). Results showed that the higher concentration Metronidazole 1.3% was well tolerated and efficacious.


Possible side effects:

  • vulvovaginal candidiasis
  • headache
  • vulvovaginal pruritus
  • nausea
  • diarrhea
  • dysmenorrhea
  • Monday, July 14, 2014

    new inhaled afrezza for diabetes

    Diabetes is a disease of the era, Which requires numerous studies and research in order

     to overcome it.

    Now offer you a new drug  and confirmed by U.S. Food and Drug Administration . it is afrezza

    (insulin human) Inhalation Powder, a rapid-acting inhaled insulin to improve glycemic

    control in adults with Type 1 and Type 2 diabetes mellitus. Afrezza is a rapid-acting

    inhaled insulin that is administered at the beginning of each meal.

    given at the start of a meal, AFREZZA dissolves immediately upon inhalation and delivers

     insulin quickly to the blood stream. Peak insulin levels are achieved within 12 to 15

    minutes of administration, mimicking the release of mealtime insulin observed in healthy 

    individuals. 


    Afrezza is not a substitute for long-acting

    insulin. Afrezza must be used in combination

    with long-acting insulin in patients with type 1

    diabetes, and it is not recommended for the

    treatment of diabetic ketoacidosis, or in

    patients who smoke.

    Afrezza has the following outcomes:

  • Proven reductions in HbA1c
  • A reduced risk of hypoglycemia vs. rapid-acting analogs
  • Less weight gain vs. rapid-acting analogs
  • Injection-free insulin delivery

  • the likely present side effect a mild, transient, non-productive cough.

    Sunday, July 13, 2014

    Imiquimod ( Aldara ) fantastic immunmodulating drug

    Imiquimod is used to treat certain skin growths or tumors,as actinic keratosis ,it is also effective in tratment of

    basal cell carcinoma,and treatment of 
     warts on the genital area , bowens disease, superficial
     squamous cell 

    carcinoma.there are multi tests run to use in other cancer as  vulvar intraepithelial neoplasia .

    methods to use : applied to clean, intact skin. Wash the affected area with mild soap and water and let your skin

    dry completely for about 10 minutes before you put on the cream ,avoid touch  lips, mouth, nostrils, or

    eyes. 
     imiquimod, has tow different concentrations of the drug (5% and 3.75%). The more-concentrated cream

    (5%) is used for cancer, genital warts, and actinic keratoses. The less-concentrated drug (3.75%) is used only for

    actinic keratoses.


    mechanism of act:
    (1  innate 
    immune system through the
     toll-like 

    receptor 7,which involved in pathogen recognition.

    cell 
     activated by imiquimod via TLR-7

    secrete cytokines as interferon alfa (INF-

    α), 
    interleukin_6 and tumor necrotic factor.

    (2   activation of
     Langerhans cells, natural

    killer 


    cells, macrophages and B-lymphocytes.


    side effects:they are little as

    skin redness, dryness scaling of skin,sunburns on treated areas

    Saturday, July 12, 2014

    Camel milk is magic food

    Historical , camel milk was a main food for arabic cultures. Camel milk is a staple food of the

    desert Bedouin tribes and is rich in fat and protein than cow's milk, It is a whole food, which

    means it contains natural nutrients sufficient to maintain life in the absence of other sources of

    nutrition, It also contains high levels of potassium, magnesium, iron, manganese, copper, sodium

    and zinc compared to cow's milk as well as it contains less cholesterol.It also contains more

    vitamin c and b 3 times more iron than 10 times the level in cow's milk, as it dramatically feeder

    where they are given in some countries for children who suffer from malnutrition, Where 


    researchers showed that the effect of camel milk in the treatment of autism without


    having any side effects on children, and in

     addition to its ability to treat food allergy and

    the problems of the gastrointestinal tract, the

     milk of camels ability to resist bacteria and

    viruses, which helps in the healing of people

    living with autoimmune diseases. there is real

    stories from arabic cultures say that camel milk

    used to treat many of diseases as breast cancer ,renal cell cancer , brain and hepatocellular

     tumors. saudian study suggest camel milk of significant benifit for people wiht diabetes . And

    found that most of the people that feed on camel milk as a staple food outlive. somalian

    research  found that camel milk contains all the vitamins. Which confirmed the scientific research

    the effectiveness of camel milk in the prevention of various cancers in laboratory animals and

    humans because of its effectiveness in preventing the formation of compounds nitroseamine in the

    body and is responsible for the creation of cancer as it is considered material against oxidation,

    which helps protect the body tissue from damage which reduces the infection of human cancers

    different. It was the discovery of a particular protein in the milk of camels effectively similar to

    the action of the hormone insulin and concentration of 40 units per liter of milk.

    Friday, July 11, 2014

    aromasin better than letrozole (femara)



    New studies suggest that aromasin more effective than femara in postmenupausal women patient with 


    metastatic breast cancer with positive hormonal receptors to estrogen and progesteron . the study show  that


      more response to aromasin belongs to biological varities of cells .it is  an irreversible,

     steroidal aromatase enzyme inactivator but femara revesible . it lead to block in estrogen 

    synthesis pathway in periphral tissues,which prevent malignant cells to grow .

    aromasin tablets contains 25 mg of exemestane.they are given  tablet once dialy .the side 


    effects of romasin  are mild or moderate near femara side effects as fatigue , insomnia , 

    headache ,hot flushes, increase sweating ,dizziness, depression, artharalgia,back pain and 

    osteoporosis,alterd appetite.

    aromasin may elevate liver functions and must seek medical advice. patients on aromasin

     follow their treatment response by tumor markers as CA15_3 and CEA, and by radiological 

    studies as fused PET_CT scan . some studies also suggest swiching  between hormonal 

    therapy as aramadix and femara and aromasin give surprising results ,although these study 

    need aproval.