Papaverine injection for erectile dysfunction

 Papaverine is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral

spasm, vasospasm and treatment of erectile dysfunction.

Papaverine hydrochloride was initially the most often used medication. Papaverine

injections relax the muscle cells present in the arterial wall, causing dilation and increased

blood flow in the penis. Several researchers have also noted that a second Papaverine 

injection reduces the blood flow out of the penis, so that the blood is trapped and the erection

is maintained. The success rate, defined by the production of an erection rigid enough for

intercourse, has been in excess of 75%.

While all PDE5 inhibitors(Sildenafil) have become the most prescribed medication for the 

treatment of ED, injection therapy still represents a cornerstone of therapy.

How to use:

Cleanse the injection site with alcohol. Using a sterile needle, inject the medicine slowly and

directly into the base of the penis as instructed by your doctor. Papaverine should not be

injected just under the skin. The injection is usually not painful, although you may feel some 

tingling in the tip of your penis. If the injection is very painful or you notice bruising or swelling

at the place of injection, that means you have been injecting the medicine under the skin.

Stop, withdraw the needle, and reposition it properly before continuing with the injection.


After you have completed the injection, put pressure on the place of injection to prevent

 bruising. Then massage your penis as instructed by your doctor. This helps the medicine

spread to all parts of the penis, so that it will work better.

Dose:
Adults—30 to 60 milligrams (mg) injected very slowly into the area of your penis as directed

by your doctor. Allow one or two minutes to completely inject the dose. Do not inject more

than one dose in a day. Also, do not use this medicine  more than three times a week.