Natesto (testosterone) Nasal Gel for hypogonadism

 the United States Food and Drug Administration (FDA) has approved Natesto (testosterone),  the first

and only testosterone nasal gel for replacement therapy in adult males for conditions

associated with a and only testosterone nasal gel for replacement therapy in adult males for

conditions associated with a and only testosterone nasal gel for replacement therapy in adult

 males for conditions associated with a and only testosterone nasal gel for replacement

therapy in adult males for conditions associated with a and only testosterone nasal gel for

replacement therapy in adult males for conditions associated with a and only testosterone

nasal gel for replacement therapy in adult males for conditions associated with a and only

testosterone nasal gel for replacement therapy in adult males for conditions associated with

a deficiency or absence of endogenous testosterone. Natesto is self-administered via a

nasal applicator thereby .

 uses and indications :
 Primary hypogonadism (congenital or

acquired):testicular failure due to conditions

such ascryptorchidism, bilateral torsion,

orchitis, vanishingtestis syndrome,

orchiectomy, Klinefelter's

syndrome,chemotherapy, or toxic damage from

alcohol or heavy metals. These men usually have low serum testosterone concentrations

and gonadotropins (follicle-stimulating hormone [FSH], luteinizing hormone [LH]) above the

normal range.Hypogonadotropic hypogonadism (congenital or acquired): idiopathic

gonadotropin or luteinizinghormone-releasing hormone (LHRH) deficiency or pituitary-

hypothalamic injury from tumors, trauma, orradiation. These men have low testosterone

serum concentrations but have gonadotropins in the normal or low range.

.2 pump actuation per nostril administered intranasally three times daily for a total daily
dose of 33 mg.

The recognized side effects:

 prostate specific antigen (PSA) increased, headache, rhinorrhea, epistaxis, nasal discomfort,

nasopharyngitis, upper respiratory tract infection (URI), sinusitis, bronchitis