Metronidazole 1.3% Vaginal Gel for vginosis

Metronidazole is a nitroimidazole antibiotic medication used particularly for anaerobic bacteria and protozoa.

 Metronidazole is an antibacterial against anaerobic organisms, amoebicide and antiprotozoal. It is the drug

of choice for first episodes of mild-to-moderate Clostridium difficile infection.

 Giardia lamblia and ameba are intestinal parasites that can cause abdominal pain and diarrhea in infected 

individuals. Trichomonas is a vaginal parasite that causes inflammation of the vagina (vaginitis). Metronidazole

selectively blocks some of the functions within the bacterial cells and the parasites resulting in their death.

The FDA approval of Metronidazole vaginal gel 1.3% was based on a phase III randomized, double-blind, placebo-

controlled, multicenter clinical trial. Metronidazole 1.3% was compared to MetroGel-Vagina (metronidazole

 vaginal gel 0.75%). Results showed that the higher concentration Metronidazole 1.3% was well tolerated and efficacious.

Possible side effects:

vulvovaginal candidiasis

headache

vulvovaginal pruritus

nausea

diarrhea

dysmenorrhea