Dexamethazone for osteoartheritis

Corticosteroids are used in musculoskeletal diseases, and offer patient relief. Injections of

corticosteroids are recommended for management of osteoarthritis (OA).

Dexamethasone is a potent synthetic member of the glucocorticoid class of steroid drugs that has 

anti-inflammatory and immunosuppressive effects. It is 25 times more potent than cortisol in its

glucocorticoid effect, while having minimum mineralocorticoid effect.

 Dexamethasone significantly decreased synovial expression of interleukin-1β and collagen I, and a

trend to decrease synovial matrix metalloproteinase3 expression. There were also significantly lower

 levels of interleukin-1β protein with dexamethasone treatment. Dexamethasone significantly

decreased fat pad expression of matrix metalloproteinase13, basic fibroblast growth factor, and

interleukin8, and a trend to decrease matrix metalloproteinase3 and transforming growth factorβ 

expression. Dexamethasone decreased joint inflammation and joint tissue degradation and was

chondroprotective in osteoartheritis.

Dexamethazone not only used for osteoartheritis, but also  used to treat many inflammatory and

autoimmune conditions, such as rheumatoid arthritis and bronchospasm.Idiopathic thrombocytopenic

purpura, decreased numbers of platelets due to an immune problem, responds to 40 mg daily for four

days; it may be administered in 14-day cycles. it also used in patient with cancer for

augmentation  the antiemetic effect of 5-HT3 receptor antagonists, such as ondansetron.

 and  maturation of the fetus' lungs in preterm labor and other many indications